There is a need for quick and reliable methods for rapid screening of drug-influenced drivers on the roadside by police. Because the window of detection in oral fluid is more similar to blood than to urine, this matrix should therefore be appropriate for screening procedures. The performance of the Rapid STAT® (Mavand Solution GmbH), DrugWipe5/5+® (Securetec Detektions-Systeme) and Dräger DrugTest® 5000 (Draeger Safety AG & Co. KGaA) on-site oral fluid devices was evaluated with random oral fluid specimens from car drivers in North Rhine-Westphalia, Germany. Additionally, some drivers were checked using an on-site urine device (DrugScreen®, NAL von Minden). During a 11-month period, 1,212 drivers were tested. Both OF and urine on-site tests were compared to serum results.